Rational Vaccines | Resources

Intramuscular vaccination of mice with the human herpes simplex virus type-1(HSV-1) VC2 vaccine, but not its parental strain HSV-1 (F) confers full protection against lethal ocular HSV-1 (McKrae) pathogenesis

Shan K. Naidu, Rafiq Nabi, Nagarjuna R. Cheemarla, Brent A. Stanfield, Paul J. Rider, Nithya Jambunathan, Vladimir N. Chouljenko, Renee Carter, Fabio Del Piero, Ingeborg Langohr, Konstantin G. Kousoulas | February 6, 2020

Duration of protection from live attenuated vs. sub unit HSV-2 vaccines in the guinea pig model of genital herpes: Reassessing efficacy using endpoints from clinical trials

David I. Bernstein, Rhonda D. Cardin, Derek A. Pullum, Fernando J. Bravo, Konstantin G. Kousoulas, David A. Dixon | March 27, 2019

Vaccine-induced antibodies target sequestered viral antigens to prevent ocular HSV-1 pathogenesis, preserve vision, and preempt productive neuronal infection.

Derek J. Royer, Joshua F. Hendrix, Chelsea M. Larabee, Alaina M. Reagan, Virginie H. Sjoelund, Danielle M. Robertson and Daniel J.J. Carr | January, 2019

The HSV-1 live attenuated VC2 vaccine provides protection against HSV-2 genital infection in the guinea pig model of genital herpes

David I. Bernstein, Derek A. Pullum, Rhonda D. Cardin, Fernando J. Bravo, David A. Dixon, Konstantin G. Kousoulas | November 14, 2018

First Impressions-the Potential of Altering Initial Host-Virus Interactions for Rational Design of Herpesvirus Vaccine Vectors

Paul J.F. Rider, Farhana Musarrat, Rafiq Nabil, Shan Naidu, and Konstantin G. Kousoulas | March 2018

The Neonatal Fc Receptor and Complement Fixation Facilitate Prophylactic Vaccine-Mediated Humoral Protection against Viral Infection in the Ocular Mucosa

Derek J. Royer, Mehan M. Carr, Hem R. Gurung, William P. Halford and Daniel J. J. Carr | July 31, 2017

Intramuscular vaccination of guinea pigs with the live-attenuated human herpes simplex vaccine VC2 stimulates a transcriptional profile of vaginal Th17 and regulatory Tr1 responses

Brent A. Stanfield, Paul J.F. Rider, John Caskey, Fabio Del Piero, Konstantin G. Kousoulas | July 17, 2017

Impact of Type I Interferon on the Safety and Immunogenicity of an Experimental Live-Attenuated Herpes Simplex Virus 1 Vaccine in Mice

Derek J. Royer, Meghan M. Carr, Anna J. Chucair-Elliott, William P. Halford, Daniel J.J. Carr | April, 2017

Vaccination of rhesus macaques with the live-attenuated HSV-1 vaccine VC2 stimulates the proliferation of mucosal T cells and germinal center responses resulting in sustained production of highly neutralizing antibodies

Brent A. Stanfield, Bapi Pahar, Vladimir N. Chouljenko, Ronald Veazey, Konstantin G. Kousoulas | December 22, 2016

A Highly Efficacious Herpes Simplex Virus 1 Vaccine Blocks Viral Pathogenesis and Prevents Corneal Immunopathology via Humoral Immunity

Derek J. Royer, Hem R. Gurung, Jeremy K. Jinkins, Joshua Geltz, Jennifer L. Wu, William P. Halford, Daniel J.J. Carr | June, 2016

Antibodies Are Required for Complete Vaccine-Induced Protection against Herpes Simplex Virus 2

William P. Halford, Joshua Geltz, Ronald J. Messer, Kim J. Hasenkru | December 15, 2015

Herpes Simplex Vaccines: Prospects of Live-attenuated HSV Vaccines to Combat Genital and Ocular infections

Brent Stanfield, Konstantin Gus Kousoulas, PhD | September 1, 2015

Herpes Simplex Virus 2 (HSV-2) Infected Cell Proteins Are among the Most Dominant Antigens of a Live-Attenuated-HSV-2 Vaccine

Joshua J. Geltz, Edward Gershburg, William P. Halford | February 6, 2015

Live attenuated virus vaccine against herpes and uses of VC2 as vector for other diseases

K. Gus Kousoulas, PhD | 2014

Pan-HSV-2 IgG Antibody In Vaccinated Mice and Guinea Pigs Correlates with Protection against Herpes Simplex Virus 2

William P. Halford, Joshua Geltz, Edward Gershburg | June 6, 2013

A Live-Attenuated HSV-2 ICP0-Virus Elicits 10 to 100 Times Greater Protection against Genital Herpes than a Glycoprotein D Subunit Vaccine

William P. Halford, Ringo Püschel, Edward Gershburg, Andrew Wilber, Svetlana Gershburg, Brandon Rakowsk | March 11, 2011

Herpes Simplex Virus 2 ICPO Mutant Viruses Are Avirulent and Immunogenic: Implications for a Genital Herpes Vaccine

William P. Halford, Ringo Püschel, Brandon Rakowski | August 17, 2010

The rational design of vaccines

Vincent W. Bramwell, Yvonne Perrie | November 15, 2005

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