Accurate HSV Testing from Home

Current HSV tests often mislead patients.


1. Visual diagnoses cannot differentiate whether HSV-1 or HSV-2 is the cause of genital disease.
2. In young women, HSV-1 now causes more than 50% of cases of anogenital herpes (Bernstein, et al, 2013).
3.  HSV-1 is the predominate cause of neonatal herpes (Jones, et al, 2014).

Swab-based tests to detect infectious herpes simplex virus 1 or 2 (HSV-1 or HSV-2) have a high false-negative rate. PCR testing for HSV-1 or HSV-2 DNA increases sensitivity, but cannot eliminate false-negatives because viral shedding is an episodic event in HSV latently infected persons.  Antibody-based testing should be the simplest and most reliable approach to detect an HSV infection that has been in progress for 4 weeks or longer. However, the current standard of care, glycoprotein G-based ELISA (e.g., Diasorin’s HerpeSelect®), can only detect antibodies against 1 of 75 HSV proteins and often yields false-negative results during the first 3 months of infection (van Rooijen, et al., 2016).

The current standard of care, glycoprotein G-based ELISA (e.g., Diasorin’s HerpeSelect®), can only detect antibodies against 1 of 75 HSV proteins.

There is an unmet need for an accurate HSV diagnostic test that individuals may use to reliably determine their HSV infection status. Rational Vaccines (RVx) will be providing a solution, the new HSV ABVIC Test, which will ship directly to clients.

Who can benefit from the HSV ABVIC Test?

  • Persons told they have “low-positive” HSV-2 antibody results, but who have no symptoms. Many such persons are HSV-2 seronegative.
  • Persons who are unsure if their symptoms are caused by HSV-1 or HSV-2.
  • Couples in which only one partner has genital herpes. There is a 1-in-3 chance both partners carry the same HSV serotype, which reduces the risk of transmission.

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